Prescriber Highlights

• Antineoplastic for lymphoreticular neoplasms or pleural & peritoneal effusions (intracavitary).

• Contraindications (relative; risk vs. benefit): Anemia, bone marrow depression, tumor cell infiltration into bone marrow, current infection, sensitivity to mechlorethamine, or patients who have received previous chemotherapy or radiotherapy.

• Adverse Effects: Bone marrow depression, GI effects (vomiting, nausea), ototoxicity (high dosages or regional perfu