Indoxacarb ± Permethrin

Indications / Actions

Indoxacarb products (Activyl®) are labeled for once a month topical application for treatment of fleas in dogs and cats. For dogs, the combination product containing permethrin (Activyl® Tickplus) is also indicated for ticks.

Indoxacarb is an oxadiazine insecticide. It is considered a pro-insecticide as it requires bio-activation in insects via esterification to a de-carbomethoxylated form of the drug. This process does not occur in mammals. After bioactivation it